Hepatocellular carcinoma on CT. The mass appears heterogeneous due to the presence of intra-tumoral fat confirmed at histology. The mass shows arterial phase enhancement with portal venous and delayed phase washout with a thin pseudocapsule (black arrow heads). The gross picture shows a large mass within the right lobe of the liver. A separate small satellite lesion is also seen (white arrow). The microscopic section (hematoxylin and eosin stain 400) shows hepatocellular carcinoma exhibiting a trabecular architecture with thickened hepatic cords and rare mitosis (black arrow).
Intrahepatic cholangiocarcinoma. The mass is iso- to hyper-intense on T2-weighted image, bright on the diffusion weighted image and hypointense on T1-weighted image. There is peripheral thin rim enhancement in the arterial phase which persists into the portal venous phase and a thick rim-like enhancement in the delayed phase without washout. Note the enhancement of the surrounding liver in arterial phase due to perfusional change caused by the tumor. The tumor shows FDG uptake on the PET scan. The gross picture shows a white lesion (white arrow). The microscopic section (hematoxylin and eosin stain 400) shows an adenocarcinoma composed of neoplastic glandular proliferation with some areas showing lumen formation (black arrow). 781b155fdc